5F ADB

5F-ADB (also known as 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products.[1] 5F-ADB is a potent agonist of the CB1 receptor,[2] though it is unclear whether it is selective for this target. 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014, and it was added to the Japanese banned drug list in December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.
Systematic (IUPAC) name
Methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
Legal status
Legal status
CA: Schedule II
DE: Anlage II (Prohibited)
Identifiers
CAS Number 1715016-75-3
PubChem CID 101895417
ChemSpider 32741709
Chemical data
Formula C20H28FN3O3
Molar mass 377.46 g·mol−1